1 Erwin H. Ackerknecht, History and Geography of the Most Important Diseases (New York: Hafner, 1965).

   2 Odin W. Anderson and Monroe Lerner, Measuring Health Levels in the United States, 1900-1958, Health Information Foundation Research Series no. 11 (New York: Foundation, 1960). Marc Lalonde, A New Perspective on the Health of Canadians: A Working Document (Ottawa: Government of Canada, April 1974). This courageous French-English report by the Canadian Federal Secretary for Health contains a multicolored centerfold documenting the change in mortality for Canada in a series of graphs.

   3 René Dubos, The Mirage of Health: Utopian Progress and Biological Change (New York: Anchor Books, 1959), was the first to effectively expose the delusion of producing "better health" as a dangerous and infectious medically sponsored disease. Thomas McKeown and Gordon McLachlan, eds., Medical History and Medical Care: A Symposium of Perspectives (New York: Oxford Univ. Press, 1971), introduce the sociology of medical pseudo-progress. John Powles, "On the Limitations of Modern Medicine," in Science, Medicine and Man (London: Pergamon, 1973), 1:1-30, gives a critical selection of recent English-language literature on this subject. For the U.S. situation consult Rick Carlson, The End of Medicine (New York: Wiley Interscience, 1975). His essay is "an empirically based brief, theoretical in nature." For his indictment of American medicine he has chosen those dimensions for which he had complete evidence of a nature he could handle. Jean-Claude Polack, La Médecine du capital (Paris: Maspero, 1970). A critique of the political trends that seek to endow medical technology with an effective impact on health levels by a "democratization of medical consumer products." The author discovers that these products themselves are shaped by a repressive and alienating bourgeois class structure. To use medicine for political liberation it will be necessary to "find in sickness, even when it is distorted by medical intervention, a protest against the existing social order."

   4 Daniel Greenberg, "The 'War on Cancer': Official Fiction and Harsh Facts," Science and Government Report, vol. 4 (December 1, 1974). This well-researched report to the layman substantiates the view that American Cancer Society proclamations that cancer is curable and progress has been made are "reminiscent of Vietnam optimism prior to the deluge."

   5 Borland's Illustrated Medical Dictionary, 25th ed. (Philadelphia: Saunders, 1974): "Iatrogenic (iatro—Gr. physician, gennan—Gr. to produce). Resulting from the activity of physicians. Originally applied to disorders induced in the patient by autosuggestion based on the physician's examination, manner, or discussion, the term is now applied to any adverse condition in a patient occurring as the result of treatment by a physician or surgeon."

   6 Heinrich Schipperges, Utopien der Medizin: Geschichte und Kritik der ärtztlichen Ideologic des 19. Jh. (Salzburg: Miiller, 1966). A useful guide to the historical literature is Richard M. Burke, An Historical Chronology of Tuberculosis, 2nd ed. (Springfield, 111.: Thomas, 1955).

   7 For an analysis of the agents and patterns that determine the epidemic spread of modern misinformation throughout a scientific community, see Derek J. de Solla Price, Little Science, Big Science (New York: Columbia Univ. Press, 1963).

   8 On the clerical nature of medical practice, see "Cléricalisme de la fonction médicale? Médecine et politique. Le 'Sacerdoce' médical. La Relation thérapeutique. Psychanalyse et christianisme," Le Semeur, suppl. 2 (1966-67).

   9J. N. Weisfert, "Das Problem des Schwindsuchtskranken in Drama und Roman," Deutscher Journalistenspiegel 3 (1927): 579-82. A guide to tuberculosis as a literary motive in 19th-century drama and novel. E. Ebstein, "Die Lungen-schwindsucht in der Weltliteratur," Zeitschrift für Bücherfreunde 5 (1913).

   10 René and Jean Dubos, The White Plague: Tuberculosis, Man and Society (Boston: Little, Brown, 1953). On the social, literary, and scientific aspects of 19th-century tuberculosis; an analysis of its incidence.

   11 Charles E. Rosenberg, The Cholera Years: The United States in 1832, 1849, and 1866 (Chicago: Univ. of Chicago Press, 1962). The New York epidemic of 1832 was a moral dilemma from which deliverance was sought in fasting and prayer. By the time of the epidemics of 1866, the culture that had produced New York slums had as well produced chloride of lime.

   12 W. J. van Zijl, "Studies on Diarrheal Disease in Seven Countries," Bulletin of the World Health Organization 35 (1966): 249-61. Reduction in diarrheal diseases is brought about by a better water supply and sanitation, never by curative intervention.

   13 R. R. Porter, The Contribution of the Biological and Medical Sciences to Human Welfare, Presidential Address to the British Association for the Advancement of Science, Swansea Meeting, 1971 (London: the Association, 1972), p. 95.

   14 N. S. Scrimshaw, C. E. Taylor, and John E. Gordon, Interactions of Nutrition and Infection (Geneva: World Health Organization, 1968).

   15 John Cassel, "Physical Illness in Response to Stress," Antologia A7, mimeographed (Cuernavaca: CIDOC [Centro Intercultural de Documentatión], 1971).

   16 One of the clearest early statements on the paramount importance of the environment is J. P. Frank, Akademische Rede vom Volkselend als der Mutter der Krankheiten (Pavia, 1790; reprint ed., Leipzig: Earth, 1960). Thomas McKeown and R. G. Record, "Reasons for the Decline in Mortality in England and Wales During the Nineteenth Century," Population Studies 16 (1962): 94-122. Edwin Chadwick, Report on the Sanitary Condition of the Labouring Population of Great Britain, 1842, ed. M. W. Flinn (Chicago: Aldine, 1965), concluded a century and a half ago that "the primary and most important measures and at the same time the most practical, and within the recognized providence of public administration, are drainage, the removal of all refuse from habitations, streets, and roads, and the improvement of the supplies of water." Max von Petterkofer, The Value of Health to a City: Two Lectures Delivered in 1873, trans. Henry E. Sigerist (Baltimore: Johns Hopkins, 1941), calculated a century ago the cost of health to the city of Munich in terms of average wages lost and medical costs created. Public services, especially better water and sewage disposal, he argued, would lower the death rate, morbidity, and absenteeism and this would pay for itself. Epidemiological research has entirely confirmed these humanistic convictions: Delpit-Morando, Radenac, and Vilain, Disparités régionales en matière de santé, Bulletin de Statistique du Ministère de la Santé et de la Sécurité Sociale No. 3, 1973; Warren Winkelstein, Jr., "Epidemiological Considerations Underlying the Allocation of Health and Disease Care Resources," International Journal of Epidemiology 1, no. 1 (1972): 69-74; F. Fagnani, Santé, consommation médicale et environnement: Problémes et méthodes (Paris: Mouton, 1973).

   17 N. D. McGlashan, ed., Medical Geography: Techniques and Field Studies (New York: Barnes & Noble, 1973). Jacques May and Donna McLelland, eds., Studies in Medical Geography, 10 vols. (New York: Hafner, 1961-71). Daniel Noin, La Géographic démographique de la France (Paris: PUF, 1973). J. Vallin, La Mortalité en France par tranches depuis 1899 (Paris: PUF, 1973). L. D. Stamp, The Geography of Life and Death (Ithaca, N.Y.: Cornell Univ. Press, 1965). E. Rodenwaldt et al., Weltseuchenatlas (Hamburg, 1956). John Melton Hunter, The Geography of Health and Disease, Studies in Geography no. 6 (Chapel Hill: Univ. of North Carolina Press, 1974).

   18 Erwin H. Ackerknecht, Therapeutics: From the Primitives to the Twentieth Century (New York: Hafner, 1973). A simple overview. J. F. D. Shrewsbury, A History of the Bubonic Plague in the British Isles (Cambridge: Cambridge Univ. Press, 1970). An outstanding example of history written by a bacteriologist and epidemiologist.

   19 For an introduction to the literature, see Steven Polgar, "Health and Human Behaviour: Areas of Interest Common to the Social and Medical Sciences," Current Anthropology 3 (April 1962): 159-205. Polgar gives a critical evaluation of each item and the responses of a large number of colleagues to his evaluation. See also Steven Polgar, "Health," in International Encyclopedia of the Social Sciences (1968), 6:330-6; Eliot Freidson, "The Sociology of Medicine: A Trend Report and Bibliography," Current Sociology, 1961-62, nos. 10-11, pp. 123-92.

   20 Paul Slack, "Disease and the Social Historian," Times Literary Supplement, March 8, 1974, pp. 233-4. A critical review article. Catherine Rollet and Agnès Souriac, l'Epidémics et mentalites: Le Choléra de 1832 en Seine-et-Oise," Annales Economies, Sociétés, Civilisations, 1974, no. 4, pp. 935-65.

   21 Alan Berg, The Nutrition Factor: Its Role in National Development (Washington, D.C.: Brookings Institution, 1973). Hans J. Teuteberg and Günter Wiegelmann, Der Wandel der Nahrungsgewohnheiten unter dm Einftuss der Industriahsierung (Gottin-gen: Vandenhoeck & Ruprecht, 1972), deal with the impact of industrialization on the quantity, quality, and distribution of food in 19th-century Europe. With the transition from subsistence on limited staples to either managed or chosen menus, the traditional regional cultures of eating, fasting, and surviving hunger were destroyed. A badly organized rich mine of bibliographic information. In the wake of Marc Bloch and Lucien Febvre, some of the most valuable research on the significance of food to power structures and health levels was done. For an orientation on the method used, consult Guy Thuillier, "Note sur les sources de 1'histoire régionale de 1'alimentation au XIXe siècle," Annales Économies, Sociétés, Civilisations, 1968, no. 6, pp. 1301-19; Guy Thuillier, "Au XIXe siècle: L'Alimentation en Nivernais," Annales, 1965, no. 6, pp. 1163-84. For a masterpiece consult Fra^ois Lebrun, Les Hommes et la mart en Anjou au 17' et 18' siecles: Essai de demographie et psychologic historiques (Paris: Mouton, 1971); A. Poitrineau, "L'Alimentation populaire en Auvergne au XVIIIe siecle," in Enquêtes, pp. 323-31. Owsei Temkin, Nutrition from Classical Antiquity to the Baroque, Human Nutrition Monograph 3, New York, 1962. For the transformation of bread into a substance machines can produce, see Siegfried Giedion, Mechanization Takes Command: A Contribution to Anonymous History (New York: Norton, 1969), especially pts. 4:2, 4:3 (on meat). Also Fernand Braudel, "Le Superflu et 1'ordinaire: Nourriture et boissons," in Civilisation matérielle et capitalisme (Paris: Colin, 1967), pp. 134-98.

   221. D. Carruthers, Impact and Economics of Community Water Supply: A Study of Rural Water Investment in Kenya, Wye College, Ashford, Kent, 1973; on the impact of water supply on health. On the improvement of rural water supplies during the 19th century: Guy Thuillier, "Pour une histoire regionale de 1'eau en Nivernais au XIXe siècle," Annales Économies, Sociétés, Civilisations, 1968, no. 1, pp. 49 ff. The improvement of water supplies changed people's attitude towards their own bodies: Guy Thuillier, "Pour une histoire de l'hygiène corporelle. Un exemple régional: le Nivernais," Revue d'histoire économique et sociale 46, no. 2 (1968): 232-53; Lawrence Wright, Clean and Decent: The Fascinating History of the Bathroom and the Water Closet and of Sundry Habits, Fashions and Accessories of the Toilet, Principally in Great Britain, France and America (Toronto: Univ. of Toronto Press, 1967). New patterns for laundry developed: Guy Thuillier, "Pour une histoire de la lessive au XIXe siècle," Annales, 1969, no. 2, pp. 355-90.

   23 Lester B. Lave and Eugene P. Seskin, "Air Pollution and Human Health," Science 169 (1970): 723-33. Jean-Paul Dessaive et al., Médecins, climat et épidémies a la fin du XVIIIe siècle (Paris: Mouton, 1972).

   24 A synthetic, well-documented argument to this point is Emanuel de Kadt, "Inequality and Health," Univ. of Sussex, January 1975. The original and longer version of this paper was written in 1972 as the introductory chapter of a book, Saludy bienestar, which should have been published in Santiago, Chile, in 1973. John Powles, "Health and Industrialisation in Britain: The Interaction of Substantive and Ideological Change," prepared for a Colloquium on the Adaptability of Man to Urban Life, First World Congress on Environmental Medicine and Biology, Paris, July 1-5, 1974. C. Ferrero, "Health and Levels of Living in Latin America," Milbank Memorial Fund Quarterly 43 (October 1965): 281-95. A decline in mortality is not to be anticipated from more expenditures on health care but from a different allocation of funds within the health sector combined with social change.

   25 Emily R. Coleman, "L'lnfanticide dans le haul moyen age," trans. A. Chamoux, Annales Economies, Societes, Civilisations, 1974, no, 2, pp. 315-35. Suggests that infanticide in the Middle Ages was demographically significant. Ansley J. Coale, "The Decline of Fertility in Europe from the French Revolution to World War II," in S. J. Behrman et al., Fertility and Family Planning (Ann Arbor: Univ. of Michigan Press, 1970). Marital fertility declined everywhere before the proportion of the population who married increased. Discrimination against the illegitimate combined with restricted access to marriage may have served to control population. This hypothesis is reinforced in J.-L. Flandrin, "Contraception, mariage et relations amoureuses dans l'Occident chrètien," Annales, 1969, no. 6, pp. 1370-90. Demographic data suggest no contraception within marriage for 17th and 18th-century France, but very low rates of illegitimacy. Contraception in marriage was near heresy, conception outside marriage a scandal. Flandrin suggests that during the 19th century sexual behavior between spouses began to be modeled on traditional behavior outside marriage. Contraception seems to have become acceptable first among peasant families rich enough to keep infant mortality low: see M. Leridon, "Fécondité et mortalité infantile dans trois villages bavarois: Une Analyse de donnees individualists du XIXe siècle," Population 5 (1969): 997-1002. Although physicians in England opposed its spread, they seemingly applied it effectively in their own lives: J. A. Banks, "Family Planning and Birth Control in Victorian Times," paper read at the Second Annual Conference, of the Society for the History of Medicine, Leicester Univ., 1972. The Catholic Church seems to have made contraception an issue only insofar as it affected the industrial middle classes: see John Thomas Noonan, Contraception: A History of Its Treatment by the Catholic Theologians and Canonists (Cambridge: Harvard Univ. Press, 1965). Philippe Aries, "Les Techniques de la mort," in Histoire des populations françaises et de leurs attitudes devant la vie depuis le XVIIIe siècle (Paris: Seuil, 1971), p. 373.

   26 So far, world hunger and world malnutrition have increased with industrial development. "One third to one half of humanity are said to be going to bed hungry every night. In the Stone Age the fraction must have been much smaller. This is the era of unprecedented hunger. Now, in the time of the greatest technical power, starvation is an institution." Marshall Sahlins, Stone Age Economics (Chicago: Aldine, 1972), p. 23.

   27 J. E. Davies and W. F. Edmundson, Epidemiology of DOT (Mount Kisco, N.Y.: Future, 1972). A good example of paradoxical disease control from Borneo: Insecticides used in villages to control malaria vectors also accumulated in cockroaches, most of which are resistant. Geckoes fed on these, became lethargic, and fell prey to cats. The cats died, rats multiplied, and with rats came the threat of epidemic bubonic plague. The army had to parachute cats into the jungle village {Conservation News, July 1973).

   28 A good example of medical persecution of innovators is given by G. Gortvay and I. Zoltan, I. Semmelweis, His Life and Work (Budapest: Akademiai Kiado, 1968), a critical biography of the first gynecologist to use antiseptic procedures in his wards. In 1848 he reduced mortality from puerperal fever by a factor of 15 and was thereupon dismissed and ostracized by his colleagues, who were offended at the idea that physicians could be carriers of death. Morton Thompson's novel The Cry and the Covenant (New York: New American Library, 1973) makes Semmelweis come alive.

   29 Charles T. Stewart, Jr., "Allocation of Resources to Health," Journal of Human Resources 6, no. 1 (1971): 103-21. Stewart classifies resources devoted to health as treatment, prevention, information, and research. In all nations of the Western Hemisphere, prevention (e.g., potable water) and education are significantly related to life expectancy, but none of the "treatment variables" are so related.

   30 Reuel A. Stallones, in Environment, Ecology, and Epidemiology, Pan-American Health Organization Scientific Publication no. 231 (Washington, September 30, 1971), shows there is a strong positive correlation in the U.S.A. between a high proportion of doctors in the general population and a high rate of coronary disease, while the correlation is strongly negative for cerebral vascular disease. Stallones points out that this says nothing about a possible influence of doctors on either. Morbidity and mortality are an integral part of the human environment and unrelated to the efforts made to control any specific disease.

   31 Alain Letourmy and François Gibert, Santé, envirmnemmt, consommations médicales: Un Modèle et son estimation à partir des donneés de mortalité; Rapport principal (Paris: CEREBE (Centre de Recherche sur le Bien-etre), June 1974). Compares mortality rates in different regions of France; they are unrelated to medical density, highly related to the fat content of the sauces typical of each region, and somewhat less to alcohol consumption.

   32 The model study on this matter at present seems to be A. L. Cochrane, Effectiveness and Efficiency: Random Reflections on Health Services, Nuffield Provincial Hospitals Trust, 1972. See also British Medical Journal, 1974, 4:5. A. Querido, Efficiency of Medical Care (New York: International Publications, 1963).

   33 Jacques M. May, "Influence of Environmental Transformation in Changing the Map of Disease," in M. Taghi Farvar and John P. Milton, eds., The Careless Technology (Garden City, N.Y.: Natural History Press, 1972), pp. 19-34. May warns that mosquito resistance to insecticides on the one hand and parasite resistance to chemotherapeutic agents on the other may have created an unanswerable challenge to human adaptation.

   34 Henry J. Parish, A History of Immunization (Edinburgh: Livingstone, 1965). Consult historical introduction for literature. The effectiveness of prevention in relation to any specific disease must be distinguished from its contribution to the volume of disease: J. H. Alston, A New Look at Infectious Disease (London: Pitman, 1967), shows how infections are replaced by new ones, without reduction in over-all volume. Keith Mellanby, Pesticides and Pollution (New York: Collins, 1967), in an easily understandable way demonstrates how the engineering mechanisms designed to reduce one infection foster others.

   35 República de Cuba, Ministerio de la Salud Pública, Cuba: Organizacion de los servicios y nivel de salud (Havana, 1974), introduction by Fidel Castro. An impressive demonstration of the shift in mortality and morbidity patterns over one decade, during which major infections on the whole island were significantly affected by a public-health campaign. Nguyen Khac Vien, "25 Anneés d'activites médico-sanitaires," Études vietnamiennes (Hanoi), no. 25, 1970.

   36 G. O. Sofoluwe, "Promotive Medicine: A Boost to the Economy of Developing Countries," Tropical and Geographical Medicine 22 (June 1970): 250-4. During the 30 years between 1935 and 1968, most curative measures used for parasitic diseases and infections of the skin and respiratory organs and for diarrhea have left "the pattern of morbidity on the whole unchanged."

   37 In Farvar and Milton, eds., The Careless Technology, several authors make this point specifically for malaria, Bancroftian filariasis (Hamon), schistosomiasis (van der Schalie), and genito-urinary infections (Farvar).

   38Bruce Mitchel, Fluoridation Bibliography, Council of Planning Librarians Exchange Bibliography no. 268 (Waterloo, Ont., March 1972). Covers the debate and especially the social scientist's perception of people's behavior regarding fluoridation in Canada.

   39 C. L. Meinert et al., "A Study of the Effects of Hypoglycemic Agents on Vascular Complications in Patients with Adult-Onset Diabetes. II. Mortality Results, 1970," Diabetes 19, suppl. 2 (1970): 789-830. G. L. Knatterud et al., "Effects of Hypoglycemic Agents on Vascular Complications in Patients with Adult-Onset Diabetes," Journal of the American Medical Association 217 (1971): 777-84. Cochrane, Effectiveness ana" Efficiency, comments on the last two. They suggest that giving tolbutamide and phenformin is definitely disadvantageous in the treatment of mature diabetics and that there is no advantage in giving insulin rather than a diet.

   40 H. Oeser, Krebsbekämpfung: Hoffnung and Realität (Stuttgart: Thieme, 1974). This is so far, to my knowledge, the most useful introduction for the general physician or layman to a critical evaluation of world literature on the effectiveness of cancer treatment. See also N. E. McKinnon, "The Effects of Control Programs on Cancer Mortality," Canadian Medical Association Journal 82 (1960): 1308-12. K. T. Evans, "Breast Cancer Symposium: Points in the Practical Management of Breast Cancer. Are Physical Methods of Diagnosis of Value?" British Journal of Surgery 56 (1969): 784-6.

   41 Edwin F. Lewison, "An Appraisal of Long-Term Results in Surgical Treatment of Breast Cancer," Journal of the American Medical Association 186 (1963): 975-8. "The most impressive feature of the surgical treatment of breast cancer is the striking similarity and surprising uniformity of long-term end results despite widely differing therapeutic techniques as reported from this country and abroad." The same can be said today.

   42 Robert Sutherland, Cancer: The Significance of Delay (London: Butterworth, 1960), pp. 196-202. Also Hedley Atkins et al., "Treatment of Early Breast Cancer: A Report after Ten Years of Clinical Trial," British Medical Journal, 1972, 2:423-9; also p. 417. D. P. Byar and Veterans Administration Cooperative Urological Research Group, "Survival of Patients with Incidentally Found Microscopic Cancer of the Prostate: Results of Clinical Trial of Conservative Treatment," Journal of Urology 108 (December 1972): 908-13. Random comparison of four treatments (placebo, estrogen, placebo and orchiectomy, and estrogen and orchiectomy) reveals no significant differences among them, nor in comparison with radical prostatectomy. For a broad survey of analogous research on cancer in various sites, see note 40 above.

   43 Ann G. Kutner, "Current Status of Steroid Therapy in Rheumatic Fever," American Heart Journal 70 (August 1965): 147-9. Rheumatic Fever Working Party of the Medical Research Council of Great Britain and Subcommittee of Principal Investigators of the American Council on Rheumatic Fever and Congenital Heart Disease, American Heart Association, "Treatment of Acute Rheumatic Fever in Children: A Cooperative Clinical Trial of ACTH, Cortisone and Aspirin," British Medical Journal, 1955, 1:555-74.

   44 Albert N. Brest, "Treatment of Coronary Occlusive Disease: Critical Review," Diseases of the Chest 45 (January 1964): 40-45. Malcolm I. Lindsay and Ralph E. Spiekerman, "Re-evaluation of Therapy of Acute Myocardial Infarction," American Heart Journal 67 (April 1964): 559-64. Harvey D. Cain et al., "Current Therapy of Cardiovascular Disease," Geriatrics 18 (July 1963): 507-18.

   45 H. G. Mather et al., "Acute Myocardial Infarction: Home and Hospital Treatment," British Medical Journal, 1971, 3:334-8.

   46 Combined Staff Clinic, "Recent Advances in Hypertension," American Journal of Medicine 39 (October 1965): 634-8.

   47 For some of the standard textbooks see Robert H. Moser, The Disease of Medical Progress: A Study of Iatrogmic Disease, 3rd ed. (Springfield, 111.: Thomas, 1969). David M. Spain, The Complications of Modem Medical Practices (New York: Grune & Stratton, 1963). H. P. Kümmerle and N. Goossens, Klinik und Therapie der Nebenwirkungen (Stuttgart: Thieme, 1973 [1st ed., I960]). R. Heintz, Erkrankungen durch Arzneimittel: Diagnostik, Klinik, Patkogenese, Therapie (Stuttgart: Thieme, 1966). Guy Duchesnay, Le Risque therapeutique (Paris: Doin, 1954). P. F. D'Arcy and J. P. Griffin, Iatrogenic Disease (New York: Oxford Univ. Press, 1972).

   48 For the evolution of jurisprudence related to this kind of torts see M. N. Zald, "The Social Control of General Hospitals," in B. S. Georgopoulos, ed., Organization Research on Health Institutions (Ann Arbor: Univ. of Michigan, Institute for Social Research, 1972). See also Angela Holder, Medical Malpractice Law (New York: Wiley, 1974).

   49 Such side-effects were studied by the Arabs. Al-Razi (A.D. 865-925), the medical chief of the hospital of Baghdad, was concerned with the medical study of iatrogenesis, according to Al-Nadim in the Fihrist, chap. 7, sec. 3. At the time of Al-Nadim (A.D. 935), three books and one letter of Al-Razi on the subject were still available: The Mistakes in the Purpose of Physicians; On Purging Fever Patients Before the Time Is Ripe; The Reason Why the Ignorant Physicians, the Common People, and the Women in Cities Are More Successful Than Men of Science in Treating Certain Diseases and the Excuses Which Physicians Make for This; and the letter: "Why a Clever Physician Does Not Have the Power to Heal All Diseases, for That Is Not Within the Realm of the Possible."

   50 See also Erwin H. Ackerknecht, "Zur Geschichte der iatrogenen Krankhei-ten," Gesnerus 27 (1970): 57-63. He distinguishes three waves, or periods, since 1750 when the study of iatrogenesis was considered important by the medical establishment. Erwin H. Ackerknecht, "Zur Geschichte der iatrogenen Erkrankungen des Nervensystems," Therapeutische Umschau/Revue thérapeutique 27, no. 6 (1970): 345-6. A short survey of medical awareness of the side-effects of drugs on the central nervous system, starting with Avicenna (980-1037) on mercury.

   51 L. Meyler, Side Effects of Drugs (Baltimore: Williams & Wilkins, 1972). Adverse Reactions Titles, a monthly bibliography of titles from approximately 3,400 biomedical journals published throughout the world; published in Amsterdam since 1966. Allergy Information Bulletin, Allergy Information Association, Weston, Ontario.

   52 P. E. Sartwell, "Iatrogenic Disease: An Epidemiological Perspective," International Journal of Health Services 4 (winter 1974): 89-93.

   53 Pharmaceutical Society of Great Britain, Identification of Drugs and Poisons (London: the Society, 1965). Reports on drug adulteration and analysis. Margaret Kreig, Black Market Medicine (Englewood Cliffs, N.J.: Prentice-Hall, 1967), reports that an increasing percentage of articles sold by legitimate professional pharmacies are inert counterfeit drugs indistinguishable in packaging and presentation from the trademarked product.

   54 Morton Mintz, By Prescription Only, 2nd ed. (Boston: Beacon Press, 1967). (For a fuller description of this book, see below, note 98, p. 67.) Solomon Garb, Undesirable Drug Interactions, 1974-75, rev. ed. (New York: Springer, 1975). Includes information on inactivation, incompatibility, potentiation, and plasma binding, as well as on interference with elimination, digestion, and test procedures.

   55 B. Opitz and H. Horn, "Verhutung iatrogener Infektionen bei Schutzimpfungen," Deutsches Gesundheitswesen 27/24 (1972): 1131-6. On infections associated with immunization procedures.

   56 Harry N. Beaty and Robert G. Petersdorf, "Iatrogenic Factors in Infectious Disease," Annals of Internal Medicine 65 (October 1966): 641-56.

   57 Every year a million people—that is, 3 to 5 percent of all hospital admissions—are admitted primarily because of a negative reaction to drugs. Nicholas Wade, "Drug Regulation: FDA Replies to Charges by Economists and Industry," Science 179 (1973): 775-7.

   58 Eugene Vayda, "A Comparison of Surgical Rates in Canada and in England and Wales," New England Journal of Medicine 289 (1973): 1224-9, shows that surgical rates in Canada in 1968 were 1.8 times greater for men and 1.6 times greater for women than in England. Discretionary operations such as tonsillectomy and adenoidectomy, hemorroidectomy, and inguinal herniorrhaphy were two or more times higher. Cholecystectomy rates were more than five times greater. The main determinants may be differences in payment of health services and available hospital beds and surgeons. Charles E. Lewis, "Variations in the Incidence of Surgery," New England Journal of Medicine 281 (1969): 880-4, finds three- to fourfold variations in regional rates for six common surgical procedures in the U.S.A. The number of surgeons available was found to be the significant predictor in the incidence of surgery. See also James C. Doyle, "Unnecessary Hysterectomies: Study of 6,248 Operations in Thirty-five Hospitals During 1948," Journal of the American Medical Association 151 (1953): 360-5. James C. Doyle, "Unnecessary Ovariectomies: Study Based on the Removal of 704 Normal Ovaries from 546 Patients," Journal of the American Medical Association 148 (1952): 1105-11. Thomas H. Weller, "Pediatric Perceptions: The Pediatrician and latric Infectious Disease," Pediatrics 51 (April 1973): 595-602.

   59 Clifton Meador, "The Art and Science of Nondisease," New England Journal of Medicine 272 (1965): 92-5. For the physician accustomed to dealing only with pathologic entities, terms such as "nondisease entity" or "nondisease" are foreign and difficult to comprehend. This paper presents, with tongue in cheek, a classification of nondisease and the important therapeutic principles based on this concept. Iatrogenic disease probably arises as often from treatment of nondisease as from treatment of disease.

   60 Abraham B. Bergman and Stanley J. Stamm, "The Morbidity of Cardiac Nondisease in School Children," New England Journal of Medicine 276 (1967): 1008-13. Gives one particular example from the "limbo where people either perceive themselves or are perceived by others to have a nonexistent disease. The ill effects accompanying some nondiseases are as extreme as those accompanying their counterpart diseases . . . the amount of disability from cardiac nondisease in children is estimated to be greater than that due to actual heart disease." See also J. Andriola, "A Note on Possible Iatrogenesis of Suicide," Psychiatry 36 (1973): 213-18.

   61 Clinical iatrogenesis has a long history. Plinius Secundus, Naturalis Historia 29.19: "To protect us against doctors there is no law against ignorance, no example of capital punishment. Doctors learn at our risk, they experiment and kill with sovereign impunity, in fact the doctor is the only one who may kill. They go further and make the patient responsible: they blame him who has succumbed." In fact, Roman law already contained some provisions against medically inflicted torts, "damnum injuria datum per medicum." Jurisprudence m Rome made the doctor legally accountable not only for ignorance and recklessness but for bumbling. A doctor who operated on a slave but did not properly follow up his convalescence had to pay the price of the slave and the loss of the master's income during his protracted sickness. Citizens were not covered by these statutes, but could avenge malpractice on their own initiative.

   62 Montesquieu, De I'esprit des lois, bk. 29, chap. 14, b (Paris: Pléiade, 1951). The Roman laws ordained that physicians should be punished for neglect or lack of skill (the Cornelian laws, De Sicariis, inst. iv. tit. 3, de lege Aquila 7). If the physician was a person of any fortune or rank, he was only condemned to deportation, but if he was of low condition he was put to death. In our institutions it is otherwise. The Roman laws were not made under the same circumstances as ours: in Rome every ignorant pretender meddled with physic, but our physicians are obliged to go through a regular course of study and to take degrees, for which reason they are supposed to understand their profession. In this passage the 17th-century philosopher demonstrates an entirely modern optimism about medical education.

   63 For German internists, the time the patient can spend face-to-face with his doctor has now been reduced to 1.7 minutes per visit. Heinrich Erdmann, Heinz-Giinther Overrath, and Wolfgang and Thure Uxkull, "Organisationspro-bleme der ärztlichen Krankenversorgung: Dargestellt am Beispiel einer mediz-inischen Universitatsklinik," Deutsches Ärzteblatt-Ärztliche Mitteilungm 71 (1974): 3421-6. In general practice, this time was (in 1963) about 3 minutes. See T. Geyer, Verschwörung (Hilchenbach: Medizinpolitischer Verlag, 1971), p. 30.

   64 For the broader issue of genetic rather than individual damage, see John W. Goffinan and Arthur R. Tamplin, "Epidemiological Studies of Carcinogenesis by Ionizing Radiation," in Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability, Univ. of California, July 1970, pp. 235-77. The presumption is all too common that where uncertainty exists about the magnitude of carcinogenic effects, it is appropriate to continue the exposure of humans to the risk. The authors show that it is neither appropriate nor good public-health practice to demand human epidemiological evidence before stopping exposure. The argument against ionizing radiation from nuclear generation of electrical energy can be applied to all medical treatment in which there is uncertainty about genetic impact. The competence of physicians to establish levels of tolerance for entire populations must be questioned on theoretical grounds.

   65 For data and further bibliography see U.S. House of Representatives, Committee on Interstate and Foreign Commerce, An Overview of Medical Malpractice, 94th Cong., 1st Sess., March 17, 1975.

   66 The maltreatment of patients has become an accepted routine; see Charles Butterworth, "Iatrogenic Malnutrition," Nutrition Today, March-April 1974. One of the largest pockets of unrecognized malnutrition in America and Canada exists, not in rural slums or urban ghettos, but in the private rooms and wards of big-city hospitals. J. Mayer, "Iatrogenic Malnutrition," New England Journal of Medicine 284 (1971): 1218.

   67 George H. Lowrey, "The Problem of Hospital Accidents to Children," Pediatrics 32 (December 1963): 1064-8.

   68 J. T. McLamb and R. R. Huntley, "The Hazards of Hospitalization," Southern Medical Journal 60 (May 1967): 469-72.

   69 "La maladie iatrogène est presque toujours a base névrotique": L. Israel, "La Maladie iatrogène," in Doamenta Sandoz, n.d.

   70 The distinction of several levels of iatrogenesis was made by Ralph Audy, "Man-made Maladies and Medicine," California Medicine, November 1970, pp. 48-53. He recognizes that iatrogenic "diseases" are only one type of man-made malady. According to their etiology, they fall into several categories: those resulting from diagnosis and treatment, those relating to social and psychological attitudes and situations, and those resulting from man-made programs for the control and eradication of disease. Besides iatrogenic clinical entities, he recognizes other maladies that have a medical etiology.

   71 "Das Schicksal des Kranken verkorpert als Symbol das Schicksal der Menschheit im Stadium einer technischen Weltentwicklung": Wolfgang Jacob, Der kranke Mensch in der technischen Welt, IX. Internationaler Fortbildungskurs fur praktische und wissenschaftliche Pharmazie der Bundesapothekerkammer in Meran (Frankfurt am Main: Werbe- und Vertriebsgesellschaft Deutscher Apotheker, 1971).

   72 James B. Quinn, "Next Big Industry: Environmental Improvement," Harvard Business Review 49 (September-October 1971): 120-30. He believes that environmental improvement is becoming a dynamic and profitable series of markets for industry that pay for themselves and in the end will represent an important addition to income and GNP. Implicitly the same argument is being made for the health-care field by the proponents of no-fault malpractice insurance.

   73 The term was used by Honoré Daumier (1810-79). See reproduction of his drawing "Nemesis medicale" in Werner Block, Der Artzt und der Tod in Bildem aus seeks Jahrhunderten (Stuttgart: Enke, 1966).